ESCO Streamline SLC-RABS 4N2.0: Advanced Compounding Aseptic Containment Isolator with Closed Restricted Access & Negative Pressure Barrier System

The Streamline® (SLC-RABS-4N2-0) Closed Restricted Access Barrier System (SLC-RABS) provides a safe and clean environment for the preparation of sterile non-hazardous drugs in compliance to the United States Pharmacopeia General Chapter <797>.

Closed Restricted Access Barrier System (cRABS) provides a full unidirectional airflow scheme for an ISO Class 5 environment for aseptic processing. SLC-RABS is designed with a rigid wall enclosure and glove port access for process manipulation; this prevents the risk of cross-contamination. The interior of the enclosure is manually sanitised with process components introduced via pass-through chambers.

As such, cRABS provide superior sterility as compared to open front clean air devices (laminar flow clean benches and Class II biological safety cabinets). These systems are a safe and efficient solution for the production of low-volume pharmaceuticals as well as with practices concerning:

• Operator aseptic technique training
• Expiration settings
• Product quality maintenance (once CSP leaves the pharmacy) 

Furthermore, cRABS can reduce operating and renovation costs by taking up less space than a traditional cleanroom facility.

• ULPA filters (as per IEST-RP-CC001.3 and HEPA (H14) filter as per EN 1822) with a typical efficiency of >99.995% at 0.1 to 0.3 microns, providing ISO Class 5 air cleanliness as per ISO 14644-1.
• Sentinel™ Gold Microprocessor controller supervises all functions and monitors airflow and pressures in real-time.
• For negatively pressured RABS, the work zone and pass-through chambers are under negative pressure to the room to maintain operator protection in the event of a breach in the system.
• Positively pressured configurations are under positive pressure to the room to ensure product protection.
• Robust dual-wall construction. The work zone is surrounded by negative pressure plenums at the sides and back. Unique Esco Dynamic Chamber™ plenum surrounds filter seals with negative pressure.
• Ergonomically angled front and oval gloveports improve reach and comfort.
• Safe-change cuff rings permit glove changing with zero risk of contaminating the work zone and/or pharmacy environment.
• Easy to clean one-piece work zone liner.
• Esco antimicrobial coating on all painted surfaces to minimize contamination.
• Sharps disposal system and hydraulic height adjustable stand are available as options.

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