Anti-ZCCHC8 antibody produced in rabbit, 1 X 100 µL (HPA037483-100UL)

Zinc finger CCHC-type containing 8 (ZCCHC8) is a nuclear protein, encoded by the gene mapped to human chromosome 12q24.31. The encoded protein contains a zinc-knuckle domain and a proline-rich region. All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. zinc finger, CCHC domain containing 8 recombinant protein epitope signature tag (PrEST) Zinc finger CCHC-type containing 8 (ZCCHC8) acts as a substrate for glycogen synthase kinase-3 (GSK3) and plays a vital role in RNA metabolism. ZCCHC8 expression is elevated in neuroblastoma patients. ZCCHC8 along with hMTR4 (an ATP-dependent RNA helicase) and the RNA-binding motif protein-7 (RBM7) forms a trimeric human nuclear exosome targeting (NEXT) complex, which stimulates exosomal degradation of non-coding RNAs. Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: •IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. •Protein array of 364 human recombinant protein fragments.

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