Collagenase Type II, Cls II, 1 g (C2-22-1G)

Collagenase Type II (Cls II) is one of the main tissue dissociation enzymes produced by Clostridium histolyticum. It aids to digest the smaller collagen fragments produced by Type I collagenase. Collagenases, a member of the matrix metalloproteinase (MMPs) family, digests collagen in the extracellular matrix (ECM). Collagens are triple helix structural proteins comprising three collagen polypeptides with high tensile strength. Collagenase Type II (Cls II) has been used: •as a component of Roswell park memorial Institute (RPMI)-1640 media to digest hepatic tissues •to perfuse murine heart for the isolation of epicardial stromal cells (EpiSC) •to digest collagenase and inject it into the intrarenal aorta abdominalis to perfuse the kidneys

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