Integrin beta 4 (ITGB4/CD104) Rabbit mAb, Monoclonal (A4596) | ABclonal Technology™

ABclonal Technology™ Integrin beta 4 (ITGB4/CD104) Rabbit mAb (A4596) is a monoclonal antibody raised in rabbit against ITGB4. It is validated for WB and ELISA. Confirmed reactivity includes Human and Mouse. The antibody has an IgG isotype and an observed molecular weight of 210kDa. It is affinity purified.

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• Host Species: Rabbit
• Isotype: IgG
• Species Reactivity: Human, Mouse
• Validated Applications: WB, ELISA
• Recommended Dilution: WB,1:500 - 1:1000; ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Purity: Affinity purification
• Observed MW: 210kDa
• UniProt ID: P16144
• Storage: Store at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Read Less