Lithium diisopropylamide, 1 X 100 g (246611-100G)

Lithium diisopropylamide (LDA) is a hindered non-nucleophilic strong base that abstracts hydrogen from active carbon. It can be prepared from diisopropylamine and butyllithium in the presence of tetrahydrofuran. Lithium diisopropylamide can be used for the generation of carbanion or enolate anions from carbonyl group-containing compounds. It can also be used as a base in: • The direct alkylation and acylation of ketones. • The aldol condensation reaction. • α-Selenation reaction. • The synthesis of α, β- unsaturated carbonyl compounds from carbonyl compounds. • The alkylation of acids, esters, amides, and nitriles. • The initiation of anionic polymerization.

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