ProCycle™ SPRI Magnetic Beads (MagBeads) for DNA Cleanup, PCR Purification & NGS Library Size Selection

ProCycle™ SPRI Magnetic Beads are superparamagnetic particles designed for high-performance DNA and RNA purification, PCR cleanup, and NGS library size selection. Using solid-phase reversible immobilization (SPRI) chemistry, these beads enable rapid, column-free purification by reversibly binding nucleic acids in the presence of PEG and salt. This allows efficient removal of primers, nucleotides, enzymes, salts, and adapter dimers, while preserving high-quality DNA. By adjusting the bead-to-sample ratio, precise fragment size selection can be achieved for next-generation sequencing workflows. The beads separate quickly on standard magnetic racks, are fully compatible with manual or automated liquid-handling platforms, and deliver consistently high recovery across a broad range of DNA fragment sizes. ProCycle™ beads are supplied ready to use, require no centrifugation steps, and perform reliably in PCR, ligation, restriction, and library prep protocols.

• SPRI-based reversible DNA/RNA binding technology
• Superparamagnetic particles for fast, residue-free magnetic separation
• High recovery of DNA fragments ≥100 bp to >10 kb
• Enables PCR cleanup, enzymatic reaction cleanup, and NGS library size selection
• Removes salts, enzymes, primers, adapter dimers, and other contaminants
• Supports dual-sided size selection by adjusting bead-to-sample ratios
• Compatible with automated liquid handlers and standard magnetic racks
• Ready-to-use formulation—no columns or centrifugation required

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