Recombinant Human Cathepsin D Protein (RP00214) | ABclonal Technology™

ABclonal Technology™ Recombinant Human Cathepsin D Protein (RP00214) is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu21-Leu412) of human Cathepsin D/CTSD (Accession #NP_001900.1) fused with a 6×His tag at the C-terminus. Purity: ≥ 95 % as determined by SDS-PAGE. Each lot is quality controlled to support reproducible results in research applications.

Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family. It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.

• Species: Human
• Expression System: HEK293 cells
• Tag: C-His
• Purity: ≥ 95 % as determined by SDS-PAGE.
• Endotoxin: < 0.1 EU/μg of the protein by LAL method.
• Bioactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >747 pmol/min/μg.
• UniProt ID: P07339
• Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
• Storage: Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.; After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.

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