Recombinant Human CCL17/TARC Protein (RP00315) | ABclonal Technology™

ABclonal Technology™ Recombinant Human CCL17/TARC Protein (RP00315) — Recombinant Recombinant Human CCL17/TARC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Ser94) of Human CCL17/TARC (Accession #NP_002978.1) fused with a His tag at the C-terminus. Purity: ≥ 95 % as determined by SDS-PAGE. Each lot is quality controlled to support reproducible results in research applications.

CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1 alpha, MIP-1 beta, MCP-1, MCP-2, MCP-3 and I-309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

• Species: Human
• Expression System: HEK293 cells
• Tag: C-His
• Purity: ≥ 95 % as determined by SDS-PAGE.
• Endotoxin: < 1 EU/μg of the protein by LAL method.
• UniProt ID: Q92583
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
• Storage: Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.; After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.

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