Thioredoxin reductase 2 (TXNRD2 ) Rabbit mAb, Monoclonal (A8884) | ABclonal Technology™

ABclonal Technology™ Thioredoxin reductase 2 (TXNRD2 ) Rabbit mAb (A8884) is a monoclonal antibody raised in rabbit against TXNRD2. It is validated for WB and ELISA. Confirmed reactivity includes Human, Mouse and Rat. The antibody has an IgG isotype and an observed molecular weight of 57kDa. It is affinity purified.

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.

• Host Species: Rabbit
• Isotype: IgG
• Species Reactivity: Human, Mouse, Rat
• Validated Applications: WB, ELISA
• Recommended Dilution: WB,1:500 - 1:2000; ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Purity: Affinity purification
• Observed MW: 57kDa
• UniProt ID: Q9NNW7
• Storage: Store at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

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