Tris(2-carboxyethyl)phosphine hydrochloride, 1 X 10 g (C4706-10G)

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) is a non-volatile solid. It is a strong reducing agent.1 It can be synthesized by the acid hydrolysis of tris(2-cyanoethyl)phosphine in refluxing aqueous HCl.1 It has various biological applications such as in vitro and in vivo reduction of disulfide bonds in various peptides and proteins. TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II). Tris(2-carboxyethyl)phosphine hydrochloride (TCEP. HCl) can be used: •As a reducing agent for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It can also be used in azide-alkyne cycloaddition reaction in the presence of a copper catalyst. •To reduce disulfide bonds in various proteins. •As a reagent for the selective reduction of disulfides in water. •To remove ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture when it is basified. •As a reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane. Storage conditions:protect from moisture.

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